{"id":3762,"date":"2023-07-21T14:32:17","date_gmt":"2023-07-21T21:32:17","guid":{"rendered":"https:\/\/grail.com\/?page_id=3762"},"modified":"2025-10-06T12:52:16","modified_gmt":"2025-10-06T19:52:16","slug":"multi-cancer-early-detection","status":"publish","type":"page","link":"https:\/\/grail.com\/multi-cancer-early-detection\/","title":{"rendered":"Multi-cancer early detection"},"content":{"rendered":"\n\n<div class=\"hero-two-columns grail-block\">\n    <div class=\"grid-container\">\n        <div class=\"grid-x hero-container to-left\">\n            <div class=\"cell small-12 large-6 flex-container container-image to-left \">\n                <div class=\"image-wrapper \">\n                    <img decoding=\"async\" class=\"image animate--stagger-in small-order-1 align-left medium-order-0\" src=\"https:\/\/assets.grail.com\/wp-content\/uploads\/2025\/09\/GRAIL-STOCK_Aug2025-48.jpg\" alt=\"\">\n                <\/div>\n                <div class=\"figure-svg show-for-xxlarge medium-order-1\">\n                    <img decoding=\"async\" class=\"image-svg  \" src=\"https:\/\/assets.grail.com\/wp-content\/uploads\/2020\/11\/svgHero.svg\" alt=\"Background texture\">\n                <\/div>\n                <div class=\"figure-svg show-for-medium-down\">\n                    <img decoding=\"async\" class=\"image-svg  \" src=\"https:\/\/assets.grail.com\/wp-content\/uploads\/2020\/11\/svgHero.svg\" alt=\"Background texture\">\n                <\/div>\n            <\/div>\n            <div class=\"cell small-12 medium-order-0 container-text animate--fade-in style-two large-6 \">\n                                    <img decoding=\"async\" class=\"logo\" src=\"\" alt=\"\">\n                                <h2 class=\"heading heading-2 title\">Early cancer detection is critical<\/h2>\n                                    <div class=\"text-description\">\n                        <p><b>Many cancers stay hidden until it is too late. <\/b><span style=\"font-weight: 200;\">The deadliest cancers are typically \u201csilent\u201d until they\u2019ve spread to other parts of the body. Late-stage cancers are more difficult to treat and typically have worse outcomes.<\/span><span style=\"font-weight: 200;\"><sup>1<\/sup><\/span><\/p>\n<p><b>We can\u2019t treat what we can\u2019t find.<\/b><span style=\"font-weight: 200;\">\u00a0Finding cancer in early stages improves overall 5-year survival rates from ~20 to 90%.<\/span><span style=\"font-weight: 200;\"><sup>2<\/sup><\/span><span style=\"font-weight: 200;\"> It is now possible to treat many cancers effectively even at Stage III, but only if we find them in time.<\/span><span style=\"font-weight: 200;\"><sup>3<\/sup><\/span><\/p>\n                    <\/div>\n                                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n<section class=\"text-plus-image --alt-layout grail-block\">\n  <div class=\"text-plus-image__container\">\n    <div class=\"text-plus-image__wrapper\">\n      <div class=\"text-plus-image__text-container\">\n        <h3 class=\"text-plus-image__heading\">Current cancer screening has a huge gap<\/h3>\n        <div class=\"text-plus-image__wysiwyg wizzywig\">\n          <p>We routinely screen for about four cancers (colon, breast, cervical, and lung); 86% of cancers are not caught by today\u2019s standard tests.<sup>4,5<\/sup><\/p>\n<p>Single-cancer screenings are an important tool for diagnosis of a handful of cancer types, but most cancer deaths are due to cancers with no recommended screening tests.<sup>4,6<\/sup><\/p>\n<p>7 in 10 cancer deaths come from cancers that lack recommended screening, including pancreatic, liver, ovarian, esophageal and others.<sup>4,6<\/sup><\/p>\n        <\/div>\n              <\/div>\n      <div class=\"text-plus-image__image-container\">\n                  <img decoding=\"async\" class=\"text-plus-image__image\" src=\"https:\/\/assets.grail.com\/wp-content\/uploads\/2025\/09\/MCED_Page1.jpg\" alt=\"\" loading=\"lazy\"\/>\n                <div class=\"sequence\">\n    <div class=\"dna\">\n    <svg width=\"773\" 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d=\"M230 832H271V950H230V832Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M368 962H405V1080H368V962Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M95 832H136V950H95V832Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M643 997H684V1115H643V997Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M265 962H302V1080H265V962Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M302 832H343V950H302V832Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M471 962H509V1080H471V962Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M0 540H28V658H0V540Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M535 705H576V823H535V705Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M166 670H204V788H166V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M714 835H750V953H714V835Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M230 540H271V658H230V540Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M368 670H405V788H368V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M95 540H136V658H95V540Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M643 705H684V823H643V705Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M265 670H302V788H265V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M302 540H343V658H302V540Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M471 670H509V788H471V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n    <\/svg>\n    <\/div>  \n<\/div>      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer base-block\"><\/div>\n\n\n<section class=\"text-plus-image --reverse grail-block\">\n  <div class=\"text-plus-image__container\">\n    <div class=\"text-plus-image__wrapper\">\n      <div class=\"text-plus-image__text-container\">\n        <h3 class=\"text-plus-image__heading\">Multi-cancer early detection screening from a blood test<\/h3>\n        <div class=\"text-plus-image__wysiwyg wizzywig\">\n          <p>Multi-cancer early detection (MCED) testing is a new approach to screening for cancer. Adding a blood-based multi-cancer early detection test can help screen for many of the deadliest cancers that don\u2019t have recommended screening today.<sup>7,8<\/sup><\/p>\n<p>&nbsp;<\/p>\n<p><iframe loading=\"lazy\" title=\"MassMutual Policy owner: Darla&#039;s Story - Cancer Signal Detected\" width=\"500\" height=\"281\" src=\"https:\/\/www.youtube.com\/embed\/7NS3ft00F40?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n        <\/div>\n              <\/div>\n      <div class=\"text-plus-image__image-container\">\n                  <img decoding=\"async\" class=\"text-plus-image__image\" src=\"https:\/\/assets.grail.com\/wp-content\/uploads\/2025\/09\/MCED_Page2.png\" alt=\"\" loading=\"lazy\"\/>\n                <div class=\"sequence\">\n    <div class=\"dna\">\n    <svg 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fill-opacity=\"0.6\"\/>\n        <path d=\"M368 670H405V788H368V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M95 540H136V658H95V540Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M643 705H684V823H643V705Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M265 670H302V788H265V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M302 540H343V658H302V540Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n        <path d=\"M471 670H509V788H471V670Z\" fill=\"white\" fill-opacity=\"0.6\"\/>\n    <\/svg>\n    <\/div>  \n<\/div>      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer base-block\"><\/div>\n\n\n<section class=\"text-plus-image --reverse grail-block\">\n  <div class=\"text-plus-image__container\">\n    <div class=\"text-plus-image__wrapper\">\n      <div class=\"text-plus-image__text-container\">\n        <h3 class=\"text-plus-image__heading\">The Galleri\u00ae multi-cancer early detection test<\/h3>\n        <div class=\"text-plus-image__wysiwyg wizzywig\">\n          <p>The Galleri test is a multi-cancer early detection (MCED) blood test that screens for cancers before they become symptomatic, including those we don\u2019t have recommended screening tests for today.<sup>9<\/sup><\/p>\n<p><sup>The Galleri test does not detect a signal for all cancers and not all cancers can be detected in the blood. False positive and false negative results do occur. The Galleri test should be used in addition to healthcare provider recommended screening tests.<\/sup><\/p>\n<p>The Galleri test delivers results you can trust as the only available MCED test with demonstrated performance in patients being screened for cancer.* Galleri can detect 50+ cancer types, with high sensitivity for many of the deadliest cancers in early stages**, and it predicts the Cancer Signal Origin (CSO) with high accuracy to guide an efficient diagnostic work-up.<sup>7,9<\/sup><\/p>\n<p><sup>*The Galleri test\u2019s key performance metrics were derived from the outcomes of an interventional clinical study of patients presenting for screening without clinical suspicion of cancer, a study population that reflects the intended use population.<br \/>\n**7 of 12 cancers that account for 2\/3 of US cancer deaths have a stage I-II sensitivity of greater than or equal to 50%.<\/sup><\/p>\n        <\/div>\n              <\/div>\n      <div 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aria-hidden=\"true\">Find out more<\/span><\/a>    <\/div>\n\n\n\n<div style=\"height:120px\" aria-hidden=\"true\" class=\"wp-block-spacer base-block\"><\/div>\n\n\n\n<div class=\"two-columns-unordered-list grail-block\">\n    <div class=\"grid-container\">\n        <div class=\"grid-x flex-container \">\n            <div class=\"cell large-5 module-information-container animate--fade-in \">\n                                    <div class=\"heading heading-2\">Important Safety Information<\/div>\n\n                                            <div class=\"text paragraph\"><p><span style=\"font-weight: 200;\">The Galleri test is recommended for use in adults with an elevated risk for cancer, such as those age 50 or older. The test does not detect all cancers and should be used in addition to routine cancer screening tests recommended by a healthcare provider. The Galleri test is intended to detect cancer signals and predict where in the body the cancer signal is located. Use of the test is not recommended in individuals who are pregnant, 21 years old or younger, or undergoing active cancer treatment. Results should be interpreted by a healthcare provider in the context of medical history, clinical signs, and symptoms. A test result of No Cancer Signal Detected does not rule out cancer. A test result of Cancer Signal Detected requires confirmatory diagnostic evaluation by medically established procedures (e.g., imaging) to confirm cancer. If cancer is not confirmed with further testing, it could mean that cancer is not present or testing was insufficient to detect cancer, including due to the cancer being located in a different part of the body. False positive (a cancer signal detected when cancer is not present) and false negative (a cancer signal not detected when cancer is present) test results do occur. <\/span><b>Rx only.<\/b><\/p>\n<\/div>\n                                                        <div class=\"heading heading-2\">Laboratory\/test information<\/div>\n\n                                            <div class=\"text paragraph\"><p><span style=\"font-weight: 200;\">The GRAIL clinical laboratory is certified under the Clinical Laboratory Improvement Amendments of 1988 (CLIA) and accredited by the College of American Pathologists. The Galleri test was developed \u2014 and its performance characteristics were determined \u2014 by GRAIL. The Galleri test has not been cleared or approved by the Food and Drug Administration. The GRAIL clinical laboratory is regulated under CLIA to perform high-complexity testing. The Galleri test is intended for clinical purposes.<\/span><\/p>\n<\/div>\n                                                <\/div>\n            <div class=\"cell large-offset-1 large-6 module-image \">\n                <img decoding=\"async\" src=\"https:\/\/assets.grail.com\/wp-content\/uploads\/2021\/02\/newsroom-desktop.svg\" alt=\"Background texture\" class=\"animate--stagger-in\">\n            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n    <div class=\"overlapping-background-text-cta to-left grail-block\">\n        <div class=\"grid-container\">\n            <div class=\"grid-x\">\n                <div class=\"cell medium-7 large-8  cell-article normal\">\n                    <div class=\"content animate--fade-in\" id=\"references\">\n                                                    \n                            <div class=\"row\">\n                                <h2 class=\"heading heading-2\">References<\/h2>\n                                                                    <div class=\"paragraphs\">\n                                        <p><sub>1. American Cancer Society. The cancer atlas. [Internet] Early detection. https:\/\/canceratlas.cancer.org\/taking-action\/early-detection\/<br \/>\n2. Surveillance, Epidemiology, and End Results (SEER) Program SEER*Stat Database: Incidence\u2009-\u2009SEER 18 Regs Research Data, 2018 Nov Sub. Includes persons aged 50-79 diagnosed 2006-2015. [GRAIL, LLC. Data on file: GA-2021-004]<br \/>\n3. If cancer is detected early, it is more amenable to curative treatment. Cancer treatment is based on the stage of the cancer. Sometimes, treatment is meant to cure the cancer. Other times, the goal is to stop the cancer from spreading further (CDC, https:\/\/www.cdc.gov\/cancer\/survivors\/patients\/treatments.htm).<br \/>\n4. US Preventive Services Task Force. A,B,C grade recommendations, cancer, screenings. [cited 2023 Oct 23]. https:\/\/www.uspreventiveservicestaskforce.org\/uspstf\/topic_search_results<br \/>\n5. NORC at the University of Chicago Cancer Detection Tool: https:\/\/cancerdetection.norc.org\/<br \/>\n6. American Cancer Society. Cancer Facts &amp; Figures 2022. https:\/\/www.cancer.org\/research\/cancer-facts-statistics\/all-cancer-facts-figures\/cancer-facts-figures-2022.html [GRAIL, LLC. Data on file: GA-2021-0065]<br \/>\n7. Klein EA, Richards D, Cohn A, et al. Clinical validation of a targeted methylation-based multi-cancer early detection test using an independent validation set. Ann Oncol. 2021;32(9):1167-77. DOI: https:\/\/doi.org\/10.1016\/j.annonc.2021.05.806.<br \/>\n8. American Cancer Society. Lifetime Risk of Developing or Dying From Cancer. https:\/\/www.cancer.org\/cancer\/risk-prevention\/understanding-cancer-risk\/lifetime-probability-of-developing-or-dying-from-cancer.html.<br \/>\n9. Schrag D, Beer TM, McDonnell CH, et al. Blood-based tests for multi-cancer early detection (PATHFINDER): a prospective cohort study. Lancet. 2023;402:1251-1260. doi: 10.1016\/S0140-6736(23)01700-2 <\/sub><\/p>\n                                    <\/div>\n                                                                                            <\/div>\n                                            <\/div>\n                <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":7,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3762","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Multi-cancer early detection - GRAIL<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/grail.com\/multi-cancer-early-detection\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Multi-cancer early detection - 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