\u00a0<\/i>Collaboration Will Leverage GRAIL\u2019s Proprietary Methylation Platform to Identify Patients Across Multiple Tumor Types in Early Stages of Disease Who Could Benefit From Novel Therapy<\/i><\/p>\n
“GRAIL has developed a novel approach to detect cancer signals in blood, regardless of whether or not the patient has clinical symptoms. We are excited to embark on this work with AstraZeneca to transform cancer outcomes through a broad, strategic collaboration,” said Sir Harpal Kumar, President, Biopharma Business and Europe at GRAIL. “Through our collaboration, we hope to provide critical information to improve the identification of patients\u00a0 who may be eligible for clinical trials and change clinical paradigms for the treatment of early-stage cancers.”<\/span><\/p>\n Across the projects within this collaboration, GRAIL will use its methylation platform to perform testing for patients enrolled in AstraZeneca\u2019s clinical trials. GRAIL will seek regulatory approval in key markets for the liquid biopsy companion diagnostics.\u00a0<\/span><\/p>\n Susan Galbraith, Executive Vice President of Oncology R&D, AstraZeneca, said: \u201cIdentifying and treating cancer early is at the heart of this strategic collaboration. Combining GRAIL\u2019s innovative blood-based methylation profiling platform with AstraZeneca\u2019s leadership in Oncology, we hope to accelerate the adoption of circulating tumor DNA across clinical trials and make our cancer medicines available at an earlier stage of disease when there is greater potential to transform patient outcomes, and even cure.\u201d<\/span><\/p>\n
\nMENLO PARK, Calif, June 2, 2022<\/b> — GRAIL, LLC, a healthcare company whose mission is to detect cancer early when it can be cured, today announced a broad strategic collaboration with AstraZeneca (LSE\/STO\/Nasdaq: AZN) to develop and commercialize companion diagnostic (CDx) assays for use with AstraZeneca\u2019s therapies. The collaboration will initially focus on developing companion diagnostic tests to identify patients with high-risk, early-stage disease, with plans to embark on numerous studies across multiple indications over the next several years. The parties are additionally planning to use GRAIL\u2019s technology to enable recruitment of patients with early-stage cancer for AstraZeneca\u2019s clinical studies.<\/span><\/p>\n