{"id":1457,"date":"2020-12-16T21:46:11","date_gmt":"2020-12-16T21:46:11","guid":{"rendered":"https:\/\/grail.wpengine.com\/?post_type=press-release&#038;p=1457"},"modified":"2021-01-12T17:56:58","modified_gmt":"2021-01-12T17:56:58","slug":"new-research-suggests-multi-cancer-early-detection-blood-test-could-reduce-late-stage-cancer-diagnoses-by-more-than-half","status":"publish","type":"press-release","link":"https:\/\/grail.com\/press-releases\/new-research-suggests-multi-cancer-early-detection-blood-test-could-reduce-late-stage-cancer-diagnoses-by-more-than-half\/","title":{"rendered":"New Research Suggests Multi-Cancer Early Detection Blood Test Could Reduce Late-Stage Cancer Diagnoses by More Than Half"},"content":{"rendered":"<p style=\"text-align: center;\">\u2014 Data Published in\u00a0<i>Cancer Epidemiology, Biomarkers &amp; Prevention\u00a0<\/i>Estimates Potential of GRAIL\u2019s Multi-Cancer Early Detection Technology \u2014<\/p>\n<p>MENLO PARK, Calif., December 16, 2020 \u2013 GRAIL, Inc., a healthcare company whose mission is to detect cancer early, today released new analyses estimating the potential of GRAIL\u2019s multi-cancer early detection blood test to find more cancers earlier and save lives.<\/p>\n<p>Published in\u00a0<a href=\"https:\/\/cebp.aacrjournals.org\/content\/early\/2020\/12\/12\/1055-9965.EPI-20-1134\"><i>Cancer Epidemiology, Biomarkers &amp; Prevention<\/i><\/a>,\u00a0a journal of the American Association for Cancer Research,\u00a0the analysis used epidemiologic modeling to estimate the potential impact of adding an annual multi-cancer early detection blood test, such as GRAIL\u2019s Galleri\u2122, to standard of care cancer screenings. The model estimates a potential reduction in late-stage (stage III and IV) cancer diagnoses by more than half in the U.S. population, aged 50-79. This decrease in late-stage diagnoses could translate to a reduction in five-year cancer deaths by 39% among those detected earlier, equating to an overall reduction of all five-year cancer deaths by 26%.<\/p>\n<p>Today, the majority of cancers are found too late when outcomes are often fatal, because most deadly cancers have no available screening tests. Current guideline-recommended screenings are critical, but in the U.S. they cover only five cancers and screen for a single cancer at a time. Cancers responsible for nearly 71% of cancer deaths have no recommended early detection screening.<\/p>\n<p>In clinical validation studies, an earlier version of Galleri demonstrated the ability to detect more than 50 types of cancers \u2014 over 45 of which lack recommended screening tests in the U.S. \u2014 with a low false positive rate of less than 1%. When a cancer was detected, the test also determined where in the body the cancer signal was located with high accuracy, all from a single blood draw.<\/p>\n<p>\u201cWhat we learned through this advanced modeling analysis is that GRAIL\u2019s multi-cancer early detection test, based on identifying methylation signals in the circulating DNA, has the potential to substantially reduce overall cancer deaths,\u201d said Joshua Ofman, MD, MSHS, Chief Medical Officer and External Affairs at GRAIL. \u201cA simple blood test like Galleri, that can detect more than 50 types of cancers and dramatically increase the cancer detection rate in the population, holds great potential to improve public health and save lives.\u201d<\/p>\n<p>The cancer \u201cinterception model\u201d \u2014 as the researchers describe it \u2014 uses published test performance data from GRAIL\u2019s foundational\u00a0<a href=\"https:\/\/grail.com\/clinical-studies\/circulating-cell-free-genome-atlas-study\/\">Circulating Cell-free Genome Atlas (CCGA) study<\/a>, including the cancer detection rate across all stages. It employs data from the U.S. Surveillance, Epidemiology, and End Results (SEER) program to quantify the stages at which cancers are currently diagnosed to understand the total number of cancers detected, and the potential reductions \u2014 or interceptions \u2014 in late-stage cancer diagnoses and associated deaths that could occur by adding GRAIL\u2019s multi-cancer early detection test to standard of care cancer screenings in the U.S population, ages 50-79.<\/p>\n<p>\u201cNearly all prior modeling efforts have focused on single cancer screening programs, leaving a gap in models addressing the potential population health benefits of multi-cancer early detection,\u201d said Christine D. Berg, MD, Special Volunteer, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health. \u201cNothing like GRAIL\u2019s test exists today, making rigorous modeling our current best approach to quantify the magnitude of the potential impact this innovative genomic technology could have on people across the U.S. through earlier cancer detection.\u201d<\/p>\n<p>Galleri is expected to be available in the U.S. in 2021 and is currently available under investigational use in GRAIL\u2019s first interventional study, PATHFINDER, where it is being used to guide clinical care. Galleri is\u00a0 also expected to be offered to patients in the United Kingdom (UK) starting in 2021 as part of a partnership with the UK\u2019s National Health Service to support its Long Term Plan for earlier cancer diagnoses in an effort to transform cancer outcomes.<\/p>\n<p><b>About GRAIL<\/b><\/p>\n<p>GRAIL is a healthcare company whose mission is to detect cancer early, when it can be cured. GRAIL is focused on saving lives and improving health by pioneering new technologies for early cancer detection. The company is using the power of next-generation sequencing, population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine\u2019s greatest challenges with Galleri\u2122, GRAIL\u2019s multi-cancer early detection test. An earlier version of Galleri demonstrated the ability to detect more than 50 types of cancers \u2014 over 45 of which lack recommended screening tests today in the U.S. \u2014 with a low false positive rate of less than 1%. GRAIL is headquartered in Menlo Park, California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u2014 Data Published in\u00a0Cancer Epidemiology, Biomarkers &amp; Prevention\u00a0Estimates Potential of GRAIL\u2019s Multi-Cancer Early Detection Technology \u2014 MENLO PARK, Calif., December 16, 2020 \u2013 GRAIL, Inc., a healthcare company whose mission is to detect cancer early, today released new analyses estimating the potential of GRAIL\u2019s multi-cancer early detection blood test to find more cancers earlier and [&hellip;]<\/p>\n","protected":false},"featured_media":466,"parent":0,"menu_order":0,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1457","press-release","type-press-release","status-publish","format-standard","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.2 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>New Research Suggests Multi-Cancer Early Detection Blood Test Could Reduce Late-Stage Cancer Diagnoses by More Than Half - 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